Provigil is an FDA approved the medication for treating narcolepsy, sleep apnea, and shift work disorder conditions. It has a unique off-label use in the form of treating Attention deficit hyperactivity disorder (ADHD) and certain other medical conditions that are related to mood disorders. It is known to exhibit antioxidative and neuroprotective effects. The medication came to sale in the year 1998. Provigil’s generic medication is Modafinil, which is found to possess the necessary potential to treat neurological fatigue developed as a result of multiple sclerosis. In fact, its medical uses are many. Off late, people have started buying Provigil online to treat medical conditions like chronic fatigue syndrome, fibromyalgia, Parkinson’s disease, spastic cerebral palsy and myotonic dystrophy. Provigil can enhance the cognition capabilities and induces alertness and attentiveness in individuals.
It is a typical alternative to many other stimulants. Modafinil is a white crystalline powder that is insoluble in cyclohexane and water. However, the racemic compound is soluble in methanol and acetone. The inactive ingredients contained in Provigil are povidone, pregelatinized starch, lactose monohydrate, croscarmellose sodium and magnesium stearate. One prime aspect to be noted here is that the full effects of the medication can be experienced only when you purchase an authentic version of the medication i.e. it should contain all the original active and inactive ingredients. Contrary to the perceptions of many, the genuine version of the medication can be purchased from exclusive Provigil online pharmacy, those of which are known for its reputation to sell only the authentic formulation of Provigil. In other words, they intend to sell Provigil in its virgin quality. Provigil is the only medication approved by US Air Force for fatigue management.
How Provigil causes the desired effect in promoting wakefulness?
The primary working mechanism of Provigil is centered on the hypothalamic region. In fact, Provigil increases the levels of hypothalamic histamine considerably. It obstructs the action that takes place in the dopamine transporter. The resultant effect of which there is an increase in the synaptic concentrations of dopamine. In fact, it also acts on the monoamine. This action, in fact, highlights the fact that Provigil affects and impact the dopamine levels in the nucleus accumbens and striatum regions. It is supposedly believed that Provigil’s mechanism of action is dependent on Orexins. Orexins are nothing but brain peptides, which is otherwise known as hypocretins. Orexin neurons are generally found within the hypothalamus region. But then it is also scattered across other parts of the brain too. Provigil causes an impact in the levels of Orexins when it is attached to certain parts of the brain that are involved in regulating the wakefulness in the body. When these neurons get activated, there is an increase in the dopamine and norepinephrine levels. This, in turn, increases the histamine levels in the histaminergic tuberomammillary neurons. Provigil 200mg tablets are highly potent in a sense that it is known to elevate the levels histamine to a far greater extent upon administration of a single dose.
Why is Provigil called as a cognitive enhancer?
According to a recent study, it has been identified that Provigil enhances the cognition levels. And that’s the reason it has been rechristened as “smart medication”. Perhaps, this finding substantiates the fact that there is an increased consumption of Provigil among the student community. Provigil improves the performance ability of an individual while performing long and complex tasks. It also enhances the planning and decision-making skills. Provigil is known to improve the efficiency of neurotransmitters, which are basically the brain chemicals that transmit signals between cells located in the brain. In fact, many students opt to buy Provigil without prescription during their time of examination and consume so as to remain focused and attentive. Its brain enhancing effect removes fatigue and improves the cognitive functioning of the brain. Persons affected by schizophrenia can be well benefitted from this medication, as it enhances the cognitive functioning. It increases the levels of neurotransmitters and through which it improves the cognitive functioning.
How Provigil offers relief from ADHD symptoms?
The potential of Provigil to treat ADHD has only been discovered in the recent past. Its working mechanism is in a way similar to other medications that treat ADHD. It stimulates the release of dopamine and norepinephrine into the brain. When the levels of these neurotransmitters are increased, it causes an increase in the attention levels, makes a person attentive and improves the concentration levels.
What are the dosage strengths of Provigil?
Provigil is available in dosage strength of 200mg. People suffering from Narcolepsy and Obstructive sleep apnea condition should take 200mg of Provigil once in a day during the morning time. Through clinical tests, it is has been observed that doses up to 400mg per day are well tolerated in individuals. People affected by Shift work disorder condition should consume 200mg of Provigil once in a day, and that too an hour prior to their work shift. The general recommendation is that people who intend to order Provigil online should be aware of the imprints contained in the tablet beforehand so that they can clearly distinguish between a genuine and fake medication. Internet pharmacies help people to get access to all the available dosages of the medication so that they can treat their problems without undergoing any side effects of the drug.
How is Provigil absorbed in the body? What is the half-life of the medication?
Provigil is basically a 1:1 racemic compound, wherein its enantiomers exhibits varied pharmacokinetics. However, the enantiomers don’t interconvert. The elimination half-life of Provigil taken in multiple doses is 15 hours. Upon consuming 200-600 mg of Provigil in a day, its enantiomers exhibit linear kinetics. The steady states of R-modafinil and total modafinil are reached after two days of dosing. Provigil is absorbed right immediately from the body upon oral consumption. The bioavailability of oral administration and aqueous suspension is almost the same. The bioavailability of Provigil is not in any ways affected by food intake. However, it is said that the time taken to attain peak concentration might get delayed by an hour. In short, the bioavailability of Provigil is 80% greater than the consumed dose. Provigil is primarily eliminated through metabolism. It has been found that less than 10% of the consumed dose is excreted in an unchanged manner. The half-life range of Provigil is somewhere between 10-12 hours.
How to take Provigil?
Provigil should be taken during the morning time to overcome daytime sleepiness. It is a medication that should not be taken for more than 12 weeks. People who are consuming the medication to treat obstructive sleep apnea might be recommended to use continuous positive airway pressure (CPAP) machine. In fact, it is an air pump that blows air into the nose while at sleep. It is to be noted that air pump doesn’t breath for the person; rather it constantly blows the air to keep the airway getting obstructed. Provigil’s usage, when combined with CPAP machine, can produce the best results.
What are the side effects of Provigil?
Unlike other medications, Provigil doesn’t cause any serious side effects. Its major side effects are a headache, nausea, diarrhea, anxiety, insomnia, nervousness, Dry mouth, Dizziness, anorexia, Flu syndrome, Dyspepsia, chest pain, chills, depression and neck rigidity. The efficacy of the medication for long-term use has not been established yet.